Keywords

• Exemestane in bulk supply
• 107868-30-4 global trade
• Hot Sale 107868-30-4

Quick Details

• ProName: Exemestane in bulk supply 107868-30-4 ...
• CasNo: 107868-30-4
• Molecular Formula: C20H24O2
• Appearance: White solid
• Application: pharmaceutical intermediates
• DeliveryTime: 1 week
• PackAge: 1kg/Aluminum foil package, 25Kg/Drum
• Port: Shenzhen,Qingdao,Guangzhou
• ProductionCapacity: Metric Ton/Day
• Purity: >99%
• Storage: Normal temperature
• Transportation: FEDEX,DHL,EMS,Special line guarantee d...
• LimitNum: 0 Metric Ton
• Moisture Content: 479
• Impurity: 0

Superiority

Exemestane in bulk supply global trade Hot Sale 107868-30-4

Exemestane is an irreversible steroid aromatase inhibitor. Its structure is similar to that of aromatase’s natural substrate, androstenedione, and acts as a pseudosubstrate. Postmenopausal women’s estrogen is mainly converted from androgen (produced by the adrenal cortex) by aromatase in the surrounding tissue. This drug irreversibly binds with the active site on aromatase to deactivate it, thus dramatically lower estrogen levels in the blood circulation of postmenopausal women. By inhibiting aromatase to lower estrogen levels, it can be used to treat hormone-dependent breast cancer in postmenopausal women.
Exemestane is suitable for treating advanced breast cancer in naturally or artificially postmenopausal women that has not responded well to tamoxifen treatment. It is also suitable for treating estrogen and progesterone receptor positive postmenopausal advanced breast cancer, and it can also be used to treat metastasized breast cancer and as adjuvant therapy for early breast cancer.

Exemestane is a steroidal irreversible CYP19 (aromatase) inhibitor. Exemestane is structurally related to natural androstenedione and acts as a false CYP19 enzyme substrate. This effect is also known as "suicide inhibition". Exemestane has been found to inhibit human placental CYP19

Details

Exemestane is a third generation, irreversible steroidal aromatase inhibitor (K_i = 10.2 nM; K_inact = 26 nM) that induces aromatase degradation leading to a decrease in estrogen levels in plasma.As an androgen analog, exemestane exhibits androgenic effects and has been shown to decrease total and HDL cholesterol, apo A₁, and total triglyceride levels.Marketed under the trade name Aromasin™, exemestane has been used to treat estrogen receptor-positive breast cancers in post-menopausal women.

Medchemexpress, HY-13632 10mg Exemestane CAS:107868-30-4 Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.