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CAS NO.164656-23-9
Dutasteride manufacturer 164656-23-9 in stock low price 164656-23-9
Dutasteride is a dual inhibitor of 5α-reductase types I and II (Kis = 6 and 7 nM, respectively).Its inhibition is time-dependent inhibitor with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively.Dutasteride decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone after castration when administered daily for 28 days at doses of 0.045 mg/kg as a solution or 0.756 mg/kg in subcutaneous microspheres. It also decreases prostate weight in large probasin-large T antigen mice, a transgenic model of prostate cancer.Formulations containing dutasteride have been used in the treatment of benign prostatic hyperplasia.
The human body contains type I and type II 5α reductase, with type II found mainly in the prostate, and type I found mainly in the liver and skin. 5α reductase is the main cause for continuous benign prostate enlargement; it promotes the transformation of testosterone in patients’ prostate into the more active dihydrotestosterone, thus causing prostate cells to enlarge and the prostate to swell. Dutasteride can inhibit both type I and II 5α reductase at the same time. This type of simultaneous inhibiting mechanism can rapidly and continuously reduce prostate size, dramatically improve urination, and reduce the risk fo acute urinary retention and its related prostate surgeries.
| Catalogue Number | D735000 |
| Chemical Name | Dutasteride |
| Synonyms | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxamide; (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide; Avodart; Avolve; GG 745; GI 198745; Veltride; |
| CAS Number | 164656-23-9 |
| Molecular Formula | C??H??F?N?O? |
| Appearance | White to Off-White Solid |
| Melting Point | 241-243°C |
| Molecular Weight | 528.53 |
| Storage | -20°C Freezer |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Category | Standards; Steroids; |
| Applications | Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia. |