Keywords

• Beta-Nicotinamide Mononucleotide（NMN） in bulk supply
• 1094-61-7 global trade
• Hot Sale 1094-61-7

Quick Details

• ProName: Beta-Nicotinamide Mononucleotide（NMN） ...
• CasNo: 1094-61-7
• Molecular Formula: C11H15N2O8P
• Appearance: White solid
• Application: pharmaceutical intermediates
• DeliveryTime: 1 week
• PackAge: 1kg/Aluminum foil package, 25Kg/Drum
• Port: Shenzhen,Qingdao,Guangzhou
• ProductionCapacity: Metric Ton/Day
• Purity: >99%
• Storage: Normal temperature
• Transportation: FEDEX,DHL,EMS,Special line guarantee d...
• LimitNum: 0 Metric Ton
• Moisture Content: <0.1040
• Impurity: 0

Superiority

Beta-Nicotinamide Mononucleotide（NMN） in bulk supply 1094-61-7 global trade Hot Sale 1094-61-7

β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD⁺; Item No. 16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD⁺ by β-NMN adenyltransferase.At 50-100 µM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt^+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function. Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD⁺ levels.

β-Nicotinamide mononucleotide is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD⁺ intermediate. It ameliorates glucose intolerance by restoring NAD⁺ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Details

3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN.